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- W2371254893 abstract "Objective:To assess the long-term toxicity of erythromycin propionate-N-acetylcy-steinate (EPAC) in rats.Methods:SD rats were randomly assigned to one of four diet groups; each group was orally supplemented either normal diets or diets with EPAC at a dose of 75, 150 or 300 mg·kg~ -1 daily for up to 90d, respectively. Results:At the dose of 300mg·kg~ -1, the rats experienced lower appetite, weight loss and vomit as well as abnormal increases of ALT, T-Bil and AST levels. The dose of 150 mg·kg~ -1 significantly escalated the serum T-Bil and AST levels. All of the abnormalities recovered in one month after the dosing of EPAC were terminated. No toxicity was observed in the 75 mg·kg~ -1 group.Conclusion:Higher dosing of EPAC could produce reversible toxicities in rats." @default.
- W2371254893 created "2016-06-24" @default.
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- W2371254893 date "2005-01-01" @default.
- W2371254893 modified "2023-09-24" @default.
- W2371254893 title "Long-term toxicity of erythromycin propionate-N-acetylcysteinate in rats" @default.
- W2371254893 hasPublicationYear "2005" @default.
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