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- W2371274301 abstract "Objective:To find a new way of establishing a rat chronic obstructive pulmonary disease(COPD)with deficiency of both lung and spleen model.Methods:The model group was established by intratracheal instillation of lipopolysaccharide(LPS)twice with exposure to cigarite smoke about 30 days.And then the rats were treated with gastric infusion of senna leaf steep.We compared the model group with the control group,through observing the general state and the changes in histopathology,measuring the thickness of airway wall.Results:The model group had the histopathological changes of chronic bronchitls and emphysema.The rats had the symptoms and sign of deficiency of both lung and spleen.The thickness of airway wall of the model gronp was higher than the control group(P0.01).Conclusion:By intratracheal instillation of LPS with exposure to cigarite smoke and treating with gastric infusion of senna leaf steep,the COPD rat model with deficiency of both lung and spleen was successfully established.This method may provide suitable rat model for the further traditional Chinese medicine research about human COPD." @default.
- W2371274301 created "2016-06-24" @default.
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- W2371274301 date "2009-01-01" @default.
- W2371274301 modified "2023-09-23" @default.
- W2371274301 title "A New way of Establishing a Rat Chronic Obstructive Pulmonary Disease with Deficiency of both Lung and Spleen Model" @default.
- W2371274301 hasPublicationYear "2009" @default.
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