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- W2371278114 abstract "To investigate the HIV-1 nef specific CD8(+) T cell responses in long-term nonprogressor (LTNP) and AIDS patient in China.Peripheral blood mononuclear cells were collected from 7 LTNPs and 9 AIDS patients, 12 males and 4 females, aged 37 (27 approximately 55). A panel of 26 overlapping peptides spanning HIV-1 nef constituting 3 peptide pools was used as antigens. The HIV-1 nef specific CD8(+) T cell responses of the LTNPs and AIDS patients were examined by IFN- ELISPOT assay. The amount of CD4(+) T cell and viral load were detected. The relationships between HIV-1 nef specific CD8(+) T cell responses and CD4(+) T cell counts and viral loads were studied.The strength of HIV-1 nef specific CD8(+) T cell responses of LTNP group was 404 +/- 33 SFC/10(6) PBMCs, significantly higher than that of the AIDS group (59 +/- 121 SFC/10(6) PBMCs). The strength of HIV-1 nef specific CD8(+) T cell responses was positively correlated with the CD4(+) T cell count. No relationship between the strength of CD8(+) T cell responses and viral load was found.HIV-1 nef specific CD8(+) T cell responses may play an important role in preventing disease progression of HIV infection. There is a cross immune response between the major HIV-1 strains in Europe and those in China." @default.
- W2371278114 created "2016-06-24" @default.
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- W2371278114 date "2004-12-02" @default.
- W2371278114 modified "2023-09-25" @default.
- W2371278114 title "[HIV-1 nef specific cytotoxic T lymphocyte responses in long-term nonprogressors and AIDS patients]." @default.
- W2371278114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15730808" @default.
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