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- W2371296055 abstract "Objective To investigate the effect and mechanism of the small interfering RNA of B-cell specific moloney leukemia virus insert site 1(Bmi-1) on the proliferation of breast cancer MCF-7 cells in vitro.Methods MCF-7 cells were transfected with different concentrations of Bmi-1-siRNA-1,then the proliferation was detected by MTT method,the expression of Bmi-1,human telomerase reverse transcriptase(hTERT)and proliferation nuclear antigen Ki-67 protein were examined using immunocytochemistry method 72hs after the transfection.Results The growth inhibition rate of MCF-7 cells increased significantly after the transfection of Bmi-1-siRNA,which showed concentration-dependent manner(P0.05);The expression of Bmi-1,hTERT and Ki-67 protein in MCF-7 cells decreased significantly(P0.05).Conclusion Bmi-1-siRNA can inhibit the proliferation of MCF-7 cells effectively,the mechanism maybe down-regulating the expression of Bmi-1,hTERT protein." @default.
- W2371296055 created "2016-06-24" @default.
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- W2371296055 date "2010-01-01" @default.
- W2371296055 modified "2023-09-24" @default.
- W2371296055 title "Inhibiting effect of small interfering RNA of Bmi-1 on the proliferation of breast cancer MCF-7 cells in vitro" @default.
- W2371296055 hasPublicationYear "2010" @default.
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