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- W2371300952 abstract "OBJECTIVE: To investigate the expression of laminin receptor (LN-R) in the patients with gastric cancer, and their correlation with invasion, metastasis and prognosis of gastric carcinoma. METHODS:Sixty-five gastric cancer and 31 adjacent noncancerous specimens, which had histological diagnosis and complete follow-up data in our hospital from 1994-1998, were detected by the immunohistochemical assay for the expression of LN-R.RESULTS:The positive rate of LN-R in the gastric cancer tissues was significantly higher than that in the adjacent noncancerous tissues (38.5% vs 9.7%;P0.05), its positive expression was at cytoplasm and membranes and associated with tumor size, morphological type of cancer, invasiveness depth, lymph node metastasis and TNM stage, but not related with sex, age, location and histological differentiation of cancer.The positive patients had higher recurrence, metastasis rate and mortality than negative ones after radical resection (P=0.046 and 0.007 9).CONCLUSIONS:There exist higher expression of LN-R in gastric cancer. The positive LN-R patients have more recurrence,metastasis than negative ones, therefore it may be a good marker for predicting invasion and metastasis of gastric cancer,and the expression of LN-R has a close relationship with prognosis of gastric cancer." @default.
- W2371300952 created "2016-06-24" @default.
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- W2371300952 date "2004-01-01" @default.
- W2371300952 modified "2023-09-24" @default.
- W2371300952 title "Expression and significance of laminin receptor in gastric cancer" @default.
- W2371300952 hasPublicationYear "2004" @default.
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