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- W2371302621 abstract "AIM To observe the anti hyperglycemic effect of sodium orthovanadate on type 2 diabetes rats. METHODS Rats were fed by highly fatted food to grow into obesity. Then values of plasma free fatty acid (FFA) were tested. Glucose disposal was measured with the hyperinsulinemic euglycemic clamp technique to assess insulin resistance in vivo. Small dose of streptozocin was injected ip with insulin resistance. Those with plasma glucose over 11 1 mmol·L -1 were assigned to type 2 diabetes model group, continually fed with sodium orthovanadate for 3 days and assayed the values of plasma glucose in fasting state. RESULTS ①Rats fed with fatted food needed more insulin to maintain normal plasma glucose, ie (0 54±0 02) U·min -1 , higher than that of normal control ( P 0 01), and the levels of FFA increased from (0 47±0 05) mmol·L -1 to (1 53±0 29) mmol·L -1 ( P 0 01); ②sodium orthovanadate had no effect on values of plasma glucose in normal controls, but it could decreased that of type 2 diabetes rats in fasting state ( P 0 05). CONCLUSION The study suggested that sodium orthovanadate can decrease the value of plasma glucose in fasting type 2 diabetes rats and that has a protective function for maltose tolerance curve." @default.
- W2371302621 created "2016-06-24" @default.
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- W2371302621 date "2003-01-01" @default.
- W2371302621 modified "2023-09-28" @default.
- W2371302621 title "Hypoglycemia effect of sodium orthovanadate on diabetes rats" @default.
- W2371302621 hasPublicationYear "2003" @default.
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