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- W2371304900 abstract "Objective:To characterize the pharmacokinetics of roxatidine acetic hydrochloride for injection.Methods:Twenty healthy male volunteers were intravenously injected with a single dose of roxatidine 37.5 mg or 75 mg.The blood samples from the volunteers were collected to measure the serum roxatidine concentration at certain time point 24 hours post-dose by LC-MS-MS.The pharmacokinetic pa- rameters were calculated using Topfit programs.Results:The main pharmacokinetics of two dosing regi- mens(37.5 and 75 mg)were as follows:t_(1/2)(3.74+0.27)vs.(3.90±0.19)h;AUC_(0-1)(727±98) vs.(1566±276)ng·h·mL~(-1);AUC_(0-∞)(733±100)vs.(1582±281)ng·h·mL~(-1);MRT(4.58±0.24) vs.(4.61±0.38)h;Cl_(tot)(52.1±8.1)vs.(48.8±9.0)L·h~(-1);Vz(280±43)vs.(274±40)L and Vss (238±31)vs.(222±25)L.Conclusion:Roxatidine acetic hydrochloride featured linear pharmacoki- netics in the dosing setting." @default.
- W2371304900 created "2016-06-24" @default.
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- W2371304900 date "2006-01-01" @default.
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- W2371304900 title "Pharmacokinetics of roxatidine acetic hydrochloride for injection" @default.
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