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- W2371305596 abstract "Objective To investigate the presence of islet autoantibodies in patients with ketosis-onset diabetes,and to analyze their clinical characteristics.Methods The lipid profile,random plasma glucose,hemoglobin A1c,pancreatic function and islet auto-antibodies(glutamic acid decarboxylase antibody [GAD-Ab],protein tyrosine phosphatase antibody [IA2-Ab]) were examined in 133 diabetic patients with ketosis-onset.The blood pressure,weight and diabetes family history were also recorded.This cohort was divided into three groups based on the presence or absence of auto-antibodies(A+ or A-) and B-cell functional reserve(B+ or B-): group 1,A+(including A+B+ and A+B-);group 2,A-B+;group 3,A-B-.Results ① The positive rates of GAD-Ab and IA2-Ab were 27.8% and 16.5%,respectively,and that of either of the 2 antibodies was 29.3%.② The age and body mass index(BMI) of group 1 were significantly younger and lower than those of group 2 and group 3(P0.01),while the random plasma glucose and high density lipoprotein cholesterol(HDL-C) of group 1 were markedly higher than those of group 2 and group 3(P0.05 and 0.01).There were 48.2% patients in group 2 having a diabetes family history,higher than the other two groups.Group 2 had a higher level of triglyceride(TG) compared with group 1(P0.05)and higher levels of fasting C peptide and postprandial C peptide compared with group 1 and group 3(P0.01).Conclusion Diabetic patients with ketosis-onset have different clinical characteristics.Auto-antibodies and B-cell functional reserve may help to identify the subtypes of diabetes,leading to different therapeutic strategies." @default.
- W2371305596 created "2016-06-24" @default.
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- W2371305596 date "2009-01-01" @default.
- W2371305596 modified "2023-09-27" @default.
- W2371305596 title "Emergent patients with ketosis-onset diabetes:an analysis of clinical characteristics" @default.
- W2371305596 hasPublicationYear "2009" @default.
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