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- W2371306830 abstract "Objective: To study the matrine on catecholamine(CA) induced guinea pig left ventricular outflow tract pacemaker cells electrophysiology anomaly and matrine antiarrhythmic intervention effect.Methods: by using conventional cells glass microelectrode recording means,observe normally perfusate group;Epinephrine(E,80 μ mol/L),Norepinephrine(NE,80 μ mol/L),Isoproterenol(Iso,80 μ mol/L) perfusate group;And epinephrine(E),norepinephrine(NE),isoproterenol(Iso) perfusion fluid respectively + matrine(100 μ mol/L) group perfusate on guinea pig left ventricular outflow tract slow reaction pacemaker cells,amplitude of action potential(APA),cell maximum diastolic potential(MDP),velocity of diastolic depolarization(VDD),maximal rate of depolarization(Vmax),50% and 80% of action potential duration(APD50 and APD80),rate of pacemaker firing(RPF).Results: compared with normal control group comparison,catecholamine perfusate group of left ventricular outflow tract slow reaction pacemaker cells after 20 min APD50were significantly shortened(P0.01),RPF,VDD significant increased(E,Iso,P0.01;NE,P0.05);APA increased,Vmax significantly increased.In different catecholamine perfusate group to join matrine can obviously shortened the APD50,APD80;And make APA decrease,Vmax slow,RPF gradually slow,steady 20 min,RPF recover normal rhythm.Conclusion: catecholamine can significantly affect the guinea pig left ventricular outflow tract slow reaction pacemaker cell electrical activity,make its autorhythmicity increases,and matrine can weaken the effect of catecholamine,reduce induced caused by the spontaneous discharge frequency increases,Matrine can block the effects of CA." @default.
- W2371306830 created "2016-06-24" @default.
- W2371306830 creator A5047160347 @default.
- W2371306830 date "2012-01-01" @default.
- W2371306830 modified "2023-10-03" @default.
- W2371306830 title "Intervention effect of Matrine on catecholamine to left ventricular outflow tract pacemaker cells electrophysiological change" @default.
- W2371306830 hasPublicationYear "2012" @default.
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