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- W2371307912 abstract "The effects of mifepristone on the cerebral ultrastructure of term pregnant rats were studied. Ten pregnant rats were divided randomly into an experimental group (n=5) and a control group (n=5) . At the 20th day of gestation, the experimental rats were given sesame oil 1 ml and mifespristone 11.5±1 mg, while the control rats weregiven only sesame oil 1 ml. After labour, the cortical tissues of the right parietal cerebrum were obtained and prepared for electron microscopic observation and analysed by stereology. Results: compared with the control group, the experimental group showed the following morphological changes: (1) Neurons swelled and membranous cytoplosmiz organoids decreased; (2) Neuropil was partially damaged and major dense lines of myelin sheath were separated; (3) Synaptic connections decreased; (4) Interstitium was swollen;(5) The numerical density of mitochondria in the experiment group was decrease,but the volume density showed no significant change. Conclusion: Mifespristone could cause ischemia-hypoxia changes in cerebrum of pregnant rats." @default.
- W2371307912 created "2016-06-24" @default.
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- W2371307912 date "2001-01-01" @default.
- W2371307912 modified "2023-09-23" @default.
- W2371307912 title "The Effects of Mifepristone on the Cerebral Tissue of Term Pregnant Rats" @default.
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