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- W2371308650 abstract "Objective To investigate the effects of experimental left varicocele(ELV) on the vascular endothelial growth factor(VEGF) and its receptor Flt-1 proteins in the epididymis of adolescent rats,attempt to discover the pathophysiology of varicocele in male infertility.Methods The ELV modle of Sprague-Dawley(SD) male adolescent rats were established,and the expression of VEGF and Flt-1 proteins in epididymis were detected by immunohistochemistry after surgery.Results In the epididymis,the cell-specific and region-specific expression of VEGF and Flt-1 protein was shown in the epididymal epithelium.Immunohistochemistry results showed notable increasing of VEGF protein expression in ELV 4-week group compared with that of the corresponding control group(P 0.01),but decreasing in ELV 8-week group.In ELV 4-week group left epididymis occurred remarkable reductions of Flt-1 protein compared with the control group(P 0.01),but there was no statistic difference between right part and control group(P 0.05),the results showed notable increasing expression in ELV 8-week(P 0.01).Conclusions ELV leads to changes in the expressions of VEGF and Flt-1 proteins in the epididymis of adolescent rats,and consequently affect spermiotelcosis,which may be one of the reasons for varicocele-induced male infertility or subfertility." @default.
- W2371308650 created "2016-06-24" @default.
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- W2371308650 date "2012-01-01" @default.
- W2371308650 modified "2023-09-23" @default.
- W2371308650 title "Effects of Experimental Varicocele on VEGF and Flt-1 in the Epididymis of Adolescent Rats" @default.
- W2371308650 hasPublicationYear "2012" @default.
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