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- W2371308970 abstract "Objective:To investigate the expression of TRAIL receptors on the cell surface and its relation to TRAIL-induced apoptosis of gastric adenocarcinoma cell lines.Methods:Apoptotic cells were determined by the propidium iodide method using flow cytometry.TRAIL-R1,R2,R3,R4 cell surface expression were evaluated by flow cytometry.Results:TRAIL- induced apoptosis of gastric adenocarcinoma cells was in a dose- and time-dependent manner.BGC-823 was more sensitive to TRAIL-induced apoptosis than SGC-7901.The rates of apoptotic cells were 59.9% and 24.3 % after treatment with TRAIL(100μg·L~(-1))for 24 h.The cell surface expression of death receptors,TRAIL-R1 and -R2 were 97.87% and 99.42% on the BGC-823 cell line,while which were 7.03% and 95.31% on the SGC-7901 cell line.The levels of cell surface expression of TRAIL-R3/DcR1 and TRAIL-R4/DcR2 decoy receptors were very low.Conclusions:Sensitivity of gastric adenocarcinoma cells to TRAIL-induced apoptosis may be related to the expression of two death-induing receptors on the cell surface,especially DR4." @default.
- W2371308970 created "2016-06-24" @default.
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- W2371308970 date "2008-01-01" @default.
- W2371308970 modified "2023-09-22" @default.
- W2371308970 title "Relation between TNF-Related Apoptosis-induing Ligand Receptors Expression and TRAIL-induced Apoptosis of Gastric Adenocarcinoma" @default.
- W2371308970 hasPublicationYear "2008" @default.
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