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- W2371330244 abstract "【Objective】 To establish the method of modified immunomagnetic enrichment combined with fluorescent immunocytochemistry to detect micrometastases in peripheral blood of breast cancer and study its significance.【Methods】The magnetic beads covalently binding epithelial cell adhesion molecule (EpiCAM) antibody (Ab) can enrich the tumor cells in peripheral blood expressing EpiCAM , combined with the method of fluorescentimmunocytochemistry to detect the tumor cells expressing cytokeratin 8/18 (stained with green fluorescence) . Thetumor cell recovery rate and the sensitivity of the detection method were evaluated by sparking the MCF-7 breastcarcinoma cell into the blood samples of volunteers. The specificity and the possibility of clinical usage of thedetection method were also determined by comparing the twenty peripheral blood samples of the normal volunteersand the twelve blood samples of the patients with advanced breast cancer.【Results】The tumor cell recovery rate ofimmunomagnetic cell enrichment ranged from 86% to 93%. One tumor cell in 107 peripheral blood mononuclearcells can be detected, with a specificity of 100%. Circulating tumor cells can be detected in 75% of the patients with stage IV breast cancer.【Conclusion】The study shows the technique is a time-saving, easily- performed, highly sensitive and specific method. The technique shows potentially great clinical value and further clinical trial is warranted." @default.
- W2371330244 created "2016-06-24" @default.
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- W2371330244 date "2005-01-01" @default.
- W2371330244 modified "2023-09-23" @default.
- W2371330244 title "Detection of Micrometastases in Peripheral Blood of Breast Cancer with Modified Immunomagnetic Enrichment Combined with Fluorescent Immunocytochemistry" @default.
- W2371330244 hasPublicationYear "2005" @default.
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