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- W2371342633 abstract "Objective To investigate the clinical pathologic features,diagnosis,differential diagnosis of primary low-grade malignant endometrial stromal sarcoma(ESS) of the ovary. Methods One case was studied histopathologically and immunohistochemically,followed by discussion through review of pertinent literature. Results The neoplasm located in the right ovary with obscure boundary.The tumor cell nests inserted in fibrous connective tissue.The tumor was typically composed of sheets of closely packed uniform cells,usually round or oval,but occasionally spindle.The tumor cells had oval or round nuclei and scanty cytoplasm.Reticulum stains showed individual investment of most of the neoplastic cells by fibrils and accentuated the prominent vascularity.Immunophenotype: tumor cells were positive for CD10,estrogen receptor(ER),progesterone receptor(PR),vimentin and smooth muscle actin(SMA),while negative for cytokeratin pan(PCK),α-inhibin,S-100,CD99,Desmin,epithelial membrane antigen(EMA),placental alkaline phosphatase(PLAP),CD117,alpha-fetoprotein,alpha fetoprotein(AFP),chromogranin a(CgA) and synaptophysin(Syn).The proliferation index of ki-67 was about 10%.Pathologic diagnosis was low-grade malignant ESS of the ovary. Conclusion ESS of ovary is a rare tumor.When evaluating an ovarian tumor with a microscopic appearance consistent with ESS,it is important to exclude a history of a uterine ESS and to suggest inspection of the uterus.ESS should be differentially diagnosed from neoplasms such as sex cord-stromal neoplasms,malignant mixed mesodermal tumor,synovial sarcoma and rhabdomyosarcoma.The useful diagnosis markers included CD10,ER,PR,PCK,α-inhibin,S-100,CD99,Desmin,EMA,PLAP,CD117,ki-67,among which CD10,ER,PR,PCK and SMA are the most useful antibodies." @default.
- W2371342633 created "2016-06-24" @default.
- W2371342633 creator A5018086213 @default.
- W2371342633 date "2012-01-01" @default.
- W2371342633 modified "2023-09-28" @default.
- W2371342633 title "Primary Low-grade Malignant Endometrial Stromal Sarcoma of the Ovary: A Case Report and Review of Literature" @default.
- W2371342633 hasPublicationYear "2012" @default.
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