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- W2371353422 abstract "Objective To investigate the protective mechanism of cyclosporine A to renal autografts in situ.Methods Thirty rabbits were divided into three groups at random (n=10 in each group), subjected to left renal in situ perfusion with normal saline (control group), HC-A solution (HC-A group) and HC-A solution containing CsA (30 ml/L, experimental group) respectively. By ~using self-made in situ cryopreservation device, the left kidney was cryopreserved in situ at 0-4 ℃ for 2 h. Then the right kidney was dissected and the left renal blood flow was opened. At 6th h and 24th h after reperfusion, blood BUN and Cr levels were determined. At 24th h, the left kidneys were ~dissected for the detection of the expression of HSP70 and NF-κB in left renal tissues. The apoptotic rate in left renal tissues was assayed by in situ end-labeling method. Results In the experimental group, the expression level of HSP70 was significantly higher, while the expression of NF-κB and ~apoptotic rate significantly lower than in the other two groups (all P~0.01 ). The blood Cr and BUN levels at two time points in experimental group were significantly lower than in the two groups (~P ~0.01 ). ~Conclusion Cyclosporine A preconditioning to kidney could protect the kidney from ~ischemia-reperfusion ~injury." @default.
- W2371353422 created "2016-06-24" @default.
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- W2371353422 date "2005-01-01" @default.
- W2371353422 modified "2023-09-24" @default.
- W2371353422 title "Cyclosporine A preconditioning to donor kidney reduced apoptosis and expression of NF-κB in renal grafts in vivo" @default.
- W2371353422 hasPublicationYear "2005" @default.
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