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- W2371353566 abstract "[Objective] To study the inhibition action of tannins from Galla chinensis against Candida albicans in biofilm in vitro.[Method] At early stage,middle stage and mature stage of biofilm formation,Candida albicans biofilm was incubated with different concentrations of tannins extracts for 48 h,and mature Candida albicans biofilm was incubated with different concentration of tannins extracts for 24,48 and 72 h,the cells inhibition rate was tested by MTT method.The morphology of Candida albicans in biofilm was observed by light microscope and the death mode was observed in the staining of AO/EB by fluorescence microscope.[Result] Tannins from Galla chinensis could inhibit biofilm formation and mature biofilm,and the inhibition was time-and-dose-dependent during the mature stage.Tannins extracts led to the biofilm deformation,morphology and structure change of Candida albicans,but without obvious apoptosis.The tannins also inhibited the budding and formation of pseudohypha.[Conclusion] Tannins from Galla chinensis could efficiently inhibit biofilm information and mature biofilm,and possibly lead to Candida albicans death by non-apoptosis pathway." @default.
- W2371353566 created "2016-06-24" @default.
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- W2371353566 date "2012-01-01" @default.
- W2371353566 modified "2023-09-23" @default.
- W2371353566 title "Intervention Effects of Tannins from Galla chinensis against Candida albicans in Biofilm" @default.
- W2371353566 hasPublicationYear "2012" @default.
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