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- W2371361330 abstract "Objective To investigate in vitro percutaneous penetration effect of different concentration of single and mixed volatile oil from Rhizoma Zingiberis( RZ),Flos Caryophyllata( FC),Fructus Litseae( FL) on total Alkaloids of Semen Strychni( TASS)Transdermal Patch through mouse skin. Methods A modified Franz diffusion cell method was used,penetration enhancing effect of 3%,5%,7% and 10% volatile oil from RZ,FC and FL on TASS Transdermal Patch through mouse skin in vitro were investigated with Azone as positive control and TASS Transdermal Patch without penetration enhancers as negative control. The content of TASS was determined by HPLC. After the best enhancing concentrations of the three kinds of volatile oils were chosen,the mixed oils were investigated by halving and pairing them as 1∶1. Results 10% volatile oil from RZ,7% volatile oil from FC,5% volatile oil from FL and 5% Azone + 5% volatile oil of RZ had the best enhancing effect among the homologous series,the average cumulative permeation volume in 8h( Q8) of TASS Transdermal Patch with them were 2. 311,2. 016,2. 656 and 2. 532( mg·cm-2) respectively; and enhancing rates( ER) in 6h were 1. 692,2. 687,3. 420 and 1. 991 respectively. Compared with the negative control group,10% volatile oil from RZ and 5% volatile oil from FL had statistical significance by T Test( P 0. 01). Conclusion 10% volatile oil from RZ,7% volatile oil from FC,5% volatile oil from FL,and 5% Azone + 5% volatile oil of RZ could enhance permeation volume of TASS from Patch through mouse skin obviously." @default.
- W2371361330 created "2016-06-24" @default.
- W2371361330 creator A5083063221 @default.
- W2371361330 date "2013-01-01" @default.
- W2371361330 modified "2023-09-23" @default.
- W2371361330 title "Percutaneous Enhancement Effect of Volatile Oil of Rhizoma Zingiberis,Flos Caryophyllata and Fructus Litseae on Total Alkaloids of Semen Strychni Transdermal Patch" @default.
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