Matches in SemOpenAlex for { <https://semopenalex.org/work/W2371381267> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2371381267 endingPage "1183" @default.
- W2371381267 startingPage "1179" @default.
- W2371381267 abstract "BACKGROUND & OBJECTIVE Endoglin is a marker of tumor angiogenesis. Increasing evidences proved that passive immunotherapy with anti-endoglin monoclonal antibody can effectively inhibit tumor growth, and xenogeneic homologous DNA vaccine can inhibit cross antitumor immunity. This study was to explore the inhibitory effect of a DNA vaccine encoding the extracellular domain of porcine endoglin (ppEDG) on tumor growth in a mouse colon carcinoma model. METHODS ppEDG was used as a DNA vaccine to actively immunize the colon carcinoma-bearing mice. Tumor volume and survival rate of the mice were observed in 3-day intervals. Microvessel density (MVD) was detected by immunohistochemistry; antibodies against self-endoglin were detected by Western blot and ELISA; the B cells that secrete auto-antibodies against self-endoglin were detected by ELISPOT assay. RESULTS Eighteen days after tumor cell inoculation, the tumor volume was significantly smaller in ppEDG-immunized group than in empty plasmid (e-p) group and normal saline (NS) group (P<0.05), and the survival time was significantly longer in ppEDG-immunized group than in the control groups (P<0.001). MVD was significantly lower in ppEDG-immunized group than in e-p group and NS group (19.2+/-4.5 vs. 76.9+/-14.4 and 81.4+/-16.9, P<0.001). The antibodies against self-endoglin were identified in ppEDG-immunized group; the major subtypes were IgG(1) and IgG(2b). The auto-antibody-producing B cells were much more in ppEDG-immunized group than in e-p group and NS group (82.5+/-14.1 vs. 3.6+/-1.3 and 4.7+/-2.0, P<0.001). CONCLUSION ppEDG DNA vaccine could induce the production of auto-antibodies against self-endoglin, which further inhibit angiogenesis and growth of colon carcinoma." @default.
- W2371381267 created "2016-06-24" @default.
- W2371381267 creator A5051845790 @default.
- W2371381267 creator A5063363666 @default.
- W2371381267 creator A5068868412 @default.
- W2371381267 date "2005-10-01" @default.
- W2371381267 modified "2023-09-26" @default.
- W2371381267 title "A DNA vaccine encoding the extracellular domain of porcine endoglin induces antitumor immunity in a mouse colon carcinoma model" @default.
- W2371381267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16219129" @default.
- W2371381267 hasPublicationYear "2005" @default.
- W2371381267 type Work @default.
- W2371381267 sameAs 2371381267 @default.
- W2371381267 citedByCount "2" @default.
- W2371381267 crossrefType "journal-article" @default.
- W2371381267 hasAuthorship W2371381267A5051845790 @default.
- W2371381267 hasAuthorship W2371381267A5063363666 @default.
- W2371381267 hasAuthorship W2371381267A5068868412 @default.
- W2371381267 hasConcept C10205521 @default.
- W2371381267 hasConcept C153911025 @default.
- W2371381267 hasConcept C159654299 @default.
- W2371381267 hasConcept C167508917 @default.
- W2371381267 hasConcept C203014093 @default.
- W2371381267 hasConcept C2776090121 @default.
- W2371381267 hasConcept C2779053233 @default.
- W2371381267 hasConcept C2780394083 @default.
- W2371381267 hasConcept C2780801004 @default.
- W2371381267 hasConcept C28328180 @default.
- W2371381267 hasConcept C502942594 @default.
- W2371381267 hasConcept C542903549 @default.
- W2371381267 hasConcept C54355233 @default.
- W2371381267 hasConcept C6061869 @default.
- W2371381267 hasConcept C86803240 @default.
- W2371381267 hasConcept C8891405 @default.
- W2371381267 hasConceptScore W2371381267C10205521 @default.
- W2371381267 hasConceptScore W2371381267C153911025 @default.
- W2371381267 hasConceptScore W2371381267C159654299 @default.
- W2371381267 hasConceptScore W2371381267C167508917 @default.
- W2371381267 hasConceptScore W2371381267C203014093 @default.
- W2371381267 hasConceptScore W2371381267C2776090121 @default.
- W2371381267 hasConceptScore W2371381267C2779053233 @default.
- W2371381267 hasConceptScore W2371381267C2780394083 @default.
- W2371381267 hasConceptScore W2371381267C2780801004 @default.
- W2371381267 hasConceptScore W2371381267C28328180 @default.
- W2371381267 hasConceptScore W2371381267C502942594 @default.
- W2371381267 hasConceptScore W2371381267C542903549 @default.
- W2371381267 hasConceptScore W2371381267C54355233 @default.
- W2371381267 hasConceptScore W2371381267C6061869 @default.
- W2371381267 hasConceptScore W2371381267C86803240 @default.
- W2371381267 hasConceptScore W2371381267C8891405 @default.
- W2371381267 hasIssue "10" @default.
- W2371381267 hasLocation W23713812671 @default.
- W2371381267 hasLocation W23713812672 @default.
- W2371381267 hasOpenAccess W2371381267 @default.
- W2371381267 hasPrimaryLocation W23713812671 @default.
- W2371381267 hasRelatedWork W1514678057 @default.
- W2371381267 hasRelatedWork W1845472102 @default.
- W2371381267 hasRelatedWork W2091566003 @default.
- W2371381267 hasRelatedWork W2143080963 @default.
- W2371381267 hasRelatedWork W2153845834 @default.
- W2371381267 hasRelatedWork W2165677345 @default.
- W2371381267 hasRelatedWork W2183712579 @default.
- W2371381267 hasRelatedWork W2224475214 @default.
- W2371381267 hasRelatedWork W2357183516 @default.
- W2371381267 hasRelatedWork W2358791962 @default.
- W2371381267 hasRelatedWork W2377588332 @default.
- W2371381267 hasRelatedWork W2381893522 @default.
- W2371381267 hasRelatedWork W2385525961 @default.
- W2371381267 hasRelatedWork W2388583097 @default.
- W2371381267 hasRelatedWork W2414453637 @default.
- W2371381267 hasRelatedWork W2470352615 @default.
- W2371381267 hasRelatedWork W2979341397 @default.
- W2371381267 hasRelatedWork W3144055737 @default.
- W2371381267 hasRelatedWork W3145168560 @default.
- W2371381267 hasRelatedWork W98205486 @default.
- W2371381267 hasVolume "24" @default.
- W2371381267 isParatext "false" @default.
- W2371381267 isRetracted "false" @default.
- W2371381267 magId "2371381267" @default.
- W2371381267 workType "article" @default.