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- W2371393334 abstract "Objective To study the effect of methylmercury on the expression of Nrf2,HO-1,γ-GCS and Gpx-1 in rat brain cortex and the intervention of taurine on it.Methods Fourty Wistar rats were randomly divided into for groups by weight,they were(1)control group,(2)low-dose of methylmercury group,(3)the high-dose of methylmercury group and(4)taurine intervention group.Before methylmercury exposure,1—3 group rats were subcutaneously injected with 0.9% NaCl in advance,while the rats in group 4 were injected with 1 mmol/kg of taurine subcutaneously.Two hours later,the control group was intraperitonally given 0.9% NaCl,group 2 was intraperitonally given 4 μmol/kg of methylmercury chloride,and groups 3 and 4 were given 12 μmol/kg of methylmercury chloride i.p five times a week for four weeks,meanwhile the taurine intervention was also given every other day 24 hours later after last exposure,the rats were killed and the cerebral cortices were taken for detecting the contents of Hg by cold vapor atomic absorption,the mRNA and protein expressions of Nrf2,HO-1,γ-GCS,GPx-1 were determined with Real-time PCR and Western blotting methods.Results Compared with control group,the mRNA and protein expressions of HO-1 and γ-GCS,and the mercury content in brain cortex of rat,in low-and high-dose methylmercury groups mercury content were significantly elevated the mRNA and protein expressions of Nrf2 in high-dose methylmercury group were significantly higher,while the expression of Gpx-1 was obviously lowered.Although the mercury content of brain cortex in rats of taurine intervention group showed no significant difference with MeHg-exposed groups but the mRNA and protein expressions of Nrf2,HO-1 and γ-GCS were all significantly reduced,Gpx-1 was significantly up-regulated.Conclusion The results suggested that methylmercury might activate Nrf2 and its downstream target genes such as HO-1 and γ-GCS and suppress antioxidase GPX-1,thereby induces oxidative stress,while taurine showed antagonistic effect on it." @default.
- W2371393334 created "2016-06-24" @default.
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- W2371393334 date "2013-01-01" @default.
- W2371393334 modified "2023-09-24" @default.
- W2371393334 title "Effect of taurine on expression of Nrf2,HO-1,γ-GCS and Gpx-1 in cerebral cortex of methylmercury exposed rat" @default.
- W2371393334 hasPublicationYear "2013" @default.
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