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- W2371400322 abstract "Objective To assess the expression of RORγt gene and Foxp3 gene in systemic lupus erythematosus (SLE) patients and to investigate the relationship between the expression of RORγt gene and Foxp3 gene in new-onset SLE. patients. Methods 39 new-onset SLE patients aged between 21 to 40 years old and 33 aged-matched healthy volunteers were involved in our study. Real-time fluorescent quantitative PCR was used to measure the expression of RORγ gene and Foxp3 gene. Data was analyzed by SPSS 11.5 statistics software. Results (1) Both the expression of RORγt gene and Foxp3 gene were higher in SLE than that of controls. ( 2) The expression of RORγt gene was positively correlated with the expression of Foxp3 gene in SLE patients. Conclusion Higher expression of RORγt gene and Foxp3 gene may play a role in the pathogenesis of SLE. The imbalance of immunoregulation produced by interaction between RORγt gene and Foxp3 gene may take part in the pathogenesis of SLE." @default.
- W2371400322 created "2016-06-24" @default.
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- W2371400322 date "2009-01-01" @default.
- W2371400322 modified "2023-09-23" @default.
- W2371400322 title "Expression of Retinoic Acid-related Orphan Nuclear Receptor-γt Gene and Forkhead Transcription Factor Foxp3 Gene in Patients with New-onset Systemic Lupus Erythematosus" @default.
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