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- W2371412874 abstract "Objective Nitric oxide(NO) plays an important role in mediating blood flow of femoral head. But the time of effect of drug on increasin g NO is very short so far,our study was to investigate the effect of sidenafil on blood flow of femoral head in dogs. Methods a)16 male mongrel dogs were divided into two groups at random. 10 dogs(Group A)were used for intrav enous sildenafil.6 dogs(Group B)were used for three main hip extracapuslar arter ies infusion of sildenafil. b)Hydrogen washout technique was used to measure changes of blood flow of the femoral head before and after administration of sildenafil. Results a)Group A: The average blood flow of femoral head was increased from(0.168 9±0.028 0) mL·min -1 ·mL -1 to(0.203 9±0.09 0 7) mL·min -1 ·mL -1 after administration of higher dose sildenafil,but it was not significant difference;The average blood flow of femoral head was increased from(0.154 1±0.042 1) mL·min -1 ·mL -1 to (0.178 3±0 .084 7) mL·min -1 ·mL -1 after administration of middle dose silden afil,but it was not significant differences. b)Group B: The average blood flow o f femoral head was all incresaed after higher dose, middle dose and lower dose o f sildenafil administration,but it was only significant increase from(0.133 0± 0.066 1) mL·min -1 ·mL -1 to (0.229 2±0.084 7) mL·min -1 ·m L -1 after higher dose of sildenafil administration;The relationship betw een blood flow of femoral head and dose of sildenafil was significant,its regre ssion equation was Y=4.184X+12.933. Conclusion Our study demons trated that sildenafil could increase blood flow of femoral head in dogs,and it was possible to investigate the effect of sidenafil on treatment of avascular n ecrosis femoral head." @default.
- W2371412874 created "2016-06-24" @default.
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- W2371412874 date "2004-01-01" @default.
- W2371412874 modified "2023-09-25" @default.
- W2371412874 title "Effect of Sildenafil on Blood Flow of the Femoral Head in Dogs" @default.
- W2371412874 hasPublicationYear "2004" @default.
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