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- W2371428837 abstract "Objective To investigate the protective effect of vitamin D on focal cerebral ischemia rats by regulating the activity of NF-κB. Methods72 male SD rats were randomly divided into sham-operative group,control group,VD-deficient group and VD-sufficient group,each had 18 rats. Rats in sham-operative group and control group received normal diet. Rats in VD-deficient group received VD-deficient diet. Rats in VD-sufficient group received VD-sufficient diet. The MCAO model was made after each group pretreated for 10 weeks. Surgical procedures of sham-operative group was the same as the above,but no thread inserted. Neuroethology evaluations for each group of rats and the cerebral pathological conformation were observed by HE staining. The expressions of nuclear factor-kappa B( NF-кB) detected by immunohistochemical and Western blot. Results The neurological severity score in VD-sufficient group was lower than that in control group( P 0. 01); the expression of NF-кB in VD-deficient group was highest than others( P 0. 01),and the expression of NF-кB in VD-sufficient group was lower than that in control group( P 0. 01). Conclusion VD has the protective effect on focal cerebral ischemia rats,and the mechanism may be related with the decreasing of NF-кB expression." @default.
- W2371428837 created "2016-06-24" @default.
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- W2371428837 date "2015-01-01" @default.
- W2371428837 modified "2023-09-24" @default.
- W2371428837 title "Protective effect of Vitamin D on focal cerebral ischemia rats by regulating the activity of NF-κB" @default.
- W2371428837 hasPublicationYear "2015" @default.
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