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- W2371434976 abstract "This paper reports the effects of exogenous nitric oxide(NO) generated from sodium nitroprusside(SNP) on the activities of hepatic antioxidant enzymes such as catalase(Cat), glutathione peroxidase(GSH Px), superoxide dismutase(SOD) and metabolizing enzymes such as aniline hydroxylase(AH), glutathione S transferase(GST), cytochrome P450(P450) and lipid peroxidation in rats. Fifteen Wistar rats were randomly divided into five groups, each group of three rats was received SNP respectively at concentration of 0(control group), 1, 2, 4 and 8 mg·kg 1 body weight by intraperitoneal injection. As compared with the control group, the activities of Cat, SOD, AH and content of P450 in SNP treated groups were significantly reduced(P0.05), and level of lipid peroxidation in the highest dose group was increased(P0.05). The activities of GST and GSH Px of the SNP treated groups were not different from that of the control group. The results of this experiment provide an indication of toxicological effect of exogenous NO." @default.
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- W2371434976 date "1999-01-01" @default.
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- W2371434976 title "Effects of exogenous nitric oxide on the activities of antioxidant enzymes and drug metabolizing enzymes in rat liver 1" @default.
- W2371434976 hasPublicationYear "1999" @default.
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