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- W2371435372 abstract "Objective: To observe the anti-hyperglycemic and anti-fugal effects of berberine.Methods: The rat models were injected into alloxan by the caudal vein once to induce diabetic model and injected into candida albicans furthermore.60 SD male rats were divided randomly into 6 groups: the normal group,model group,4 control groups which were fed with FCZ,BBR(high dose,300mg·kg-1·d-1),BBR(low dose,150mg·kg-1·d-1) and BBR combined with FCZ.After 2 weeks,The fasting blood glucose(FBG),blood serum TNF-α,the fugal colony forming unit(CFU) and pathological changes by PAS staining of Hepatic and renal tissues were detected and observed respectively.Results:Treatment of BBR(150,300mg·kg-1·d-1) and combined with FCZ decreased fasting blood glucose,blood serum TNF-α significantly,showing marked difference(P0.05) as compared with those in the model group.The antifungal action of high dose BBR and FCZ group were greater than the other.Hepatocytes microsteatosis,enlarged glomerular volume,tubular epithelial cells vacuolar degeneration,inflammatory cell infiltration and numerous hyphae and spores were observed in the model group.The liver and kidney stained yellow,while morphology showed normally,no hypha and spore were observed in high dose BBR group.The pathological change in low dose BBR and BBR combined with FCZ groups were improved as compared with the model group.Conclusion: BBR can decrease the blood glucose,blood serum TNF-α concentration,anti-candida albicans dose dependently.It is concluded that BBR is effective in the treatment of DM complicated with systemically candida albicans infection." @default.
- W2371435372 created "2016-06-24" @default.
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- W2371435372 date "2010-01-01" @default.
- W2371435372 modified "2023-09-26" @default.
- W2371435372 title "Experimental Study of Berberine on Diabetes Mellitus Complicated with Systemically Candida Albicans Infection" @default.
- W2371435372 hasPublicationYear "2010" @default.
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