FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2371440552> ?p ?o ?g. }

• W2371440552 abstract "OBJECTIVE To study the pharmacokinetics amlodipine fixed-dose combination amlodipine / benazepril 5 /10 mg capsule in healthy volunteers and to provide evidence for its clinical application. METHODS Twenty-four healthy volunteers were divided to 3 groups with male and female half by half randomly,a single oral dose 1,2,3 capsules( 5,10 or 15 mg amlodipine respectively) was given to 8 healthy volunteers and 14 d consecutive administration( Qd) multiple oral doses 2 capsules( 10 mg amlodipine) were given to the 8 healthy volunteers the mid-dose group in this open randomized design. Plasma concentrationamlodipine was determined by ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry( UPLCESI-MS / MS),the main pharmacokinetic parameters were calculated by DAS2. 0 program using non compartment analysis( published by Mathematical Pharmacology Professional Committee China,Shanghai,China). RESULTS After the healthy volunteers received a single dose 1,2,3 capsules( 5,10,15 mg amlodipine),the main pharmacokinetic parameters amlodipine were as follows: t1 /2were( 33. 5 ± 6. 2),( 36. 1 ± 7. 6),( 39. 8 ± 12. 5) h; tmaxwere( 6. 0 ± 1. 1),( 7. 0 ± 3. 4),( 5. 6 ± 3. 0) h;ρmax( 4. 37 ± 1. 37),( 7. 23 ± 1. 81),( 14. 71 ± 3. 14) ng· m L- 1; AUC0 →144were( 167. 7 ± 35. 9),( 283. 8 ± 47. 6),( 574. 9 ± 159. 0) ng·h·m L- 1; AUC0 →∞were( 176. 8 ± 40. 2),( 304. 1 ± 54. 8),( 628. 2 ± 197. 5) ng·h·m L- 1; V /F were( 1 389. 6 ± 231. 5),( 1 724. 4 ± 269. 2),( 1 414. 2 ± 342. 6) L; MRT0-144were( 47. 8 ± 4. 0),( 51. 1 ± 9. 9),( 52. 9 ± 13. 9) h; CL /F were( 29. 5 ± 6. 5),( 34. 0 ± 7. 2),( 25. 9 ± 7. 6) L·h- 1,respectively. In the dose profile 5-15 mg,AUC0 →144,AUC0-∞and ρmaxamlodipine increased with dose,but not proportionally; the statistical results showed that t1 /2,V / F,CL / F,MRT0-144 and tmaxhad no significant difference( P 0. 05) between three groups,whereas there were increasing tendency t1 /2and MRT0-144 between three groups,the t1 /2values single high dose group increased by 6 and 3 h compared with single middle and low dose groups. Steady state concentration was achieved after 14 d consecutive administration test drug,ρmax ss was( 24. 03 ± 5. 56) ng·m L- 1,ρmin sswas( 15. 64 ± 3. 93) ng·m L- 1,AUC0 ~ 24sswas( 463. 7 ± 121. 1) ng·h·m L- 1and DF was( 0. 4 ± 0. 1),respectively. Statistical analys is indicated that these ρmax,AUC0-24 ssvalues multiple dose group were obviously higher than the ρmax,AUC0-∞the single 10 mg dose group with p values less than 0. 05 which confirmed that obvious accumulation amlodipine in human plasma occurred after multiple doses administration. CONCLUSION The established UPLCESI-MS / MS method is simple,rapid,sensitive and accuracy,and can be used for the study clinical pharmacokinetics of amlodipine. The dynamics amlodipine in vivo are nonlinear in the dosage 5-15 mg,no gender difference is found in the main pharmacokinetic parameters amlodipine,and there is obvious accumulation amlodipine besylate in human plasma found after repeated administration. Amlodipine besylate is well tolerated and no serous adverse reaction is observed during the trail." @default.
• W2371440552 created "2016-06-24" @default.
• W2371440552 creator A5049320800 @default.
• W2371440552 date "2014-01-01" @default.
• W2371440552 modified "2023-09-23" @default.
• W2371440552 title "Pharmacokinetics Amlodipine Fixed-dose Combination Amlodipine / Benazepril 5 /10 mg Capsule in Healthy Volunteers" @default.
• W2371440552 hasPublicationYear "2014" @default.
• W2371440552 type Work @default.
• W2371440552 sameAs 2371440552 @default.
• W2371440552 citedByCount "0" @default.
• W2371440552 crossrefType "journal-article" @default.
• W2371440552 hasAuthorship W2371440552A5049320800 @default.
• W2371440552 hasConcept C112705442 @default.
• W2371440552 hasConcept C126322002 @default.
• W2371440552 hasConcept C126894567 @default.
• W2371440552 hasConcept C2776623344 @default.
• W2371440552 hasConcept C2777363265 @default.
• W2371440552 hasConcept C2778778583 @default.
• W2371440552 hasConcept C2779646130 @default.
• W2371440552 hasConcept C59822182 @default.
• W2371440552 hasConcept C71924100 @default.
• W2371440552 hasConcept C84393581 @default.
• W2371440552 hasConcept C86803240 @default.
• W2371440552 hasConcept C98274493 @default.
• W2371440552 hasConceptScore W2371440552C112705442 @default.
• W2371440552 hasConceptScore W2371440552C126322002 @default.
• W2371440552 hasConceptScore W2371440552C126894567 @default.
• W2371440552 hasConceptScore W2371440552C2776623344 @default.
• W2371440552 hasConceptScore W2371440552C2777363265 @default.
• W2371440552 hasConceptScore W2371440552C2778778583 @default.
• W2371440552 hasConceptScore W2371440552C2779646130 @default.
• W2371440552 hasConceptScore W2371440552C59822182 @default.
• W2371440552 hasConceptScore W2371440552C71924100 @default.
• W2371440552 hasConceptScore W2371440552C84393581 @default.
• W2371440552 hasConceptScore W2371440552C86803240 @default.
• W2371440552 hasConceptScore W2371440552C98274493 @default.
• W2371440552 hasLocation W23714405521 @default.
• W2371440552 hasOpenAccess W2371440552 @default.
• W2371440552 hasPrimaryLocation W23714405521 @default.
• W2371440552 hasRelatedWork W15232820 @default.
• W2371440552 hasRelatedWork W1987516501 @default.
• W2371440552 hasRelatedWork W1997360771 @default.
• W2371440552 hasRelatedWork W2022383140 @default.
• W2371440552 hasRelatedWork W2065247092 @default.
• W2371440552 hasRelatedWork W2094169525 @default.
• W2371440552 hasRelatedWork W2123194195 @default.
• W2371440552 hasRelatedWork W2131211464 @default.
• W2371440552 hasRelatedWork W2167769397 @default.
• W2371440552 hasRelatedWork W2172304064 @default.
• W2371440552 hasRelatedWork W2349400912 @default.
• W2371440552 hasRelatedWork W2378800729 @default.
• W2371440552 hasRelatedWork W2418513456 @default.
• W2371440552 hasRelatedWork W2429827659 @default.
• W2371440552 hasRelatedWork W2475254384 @default.
• W2371440552 hasRelatedWork W3006365185 @default.
• W2371440552 hasRelatedWork W3209881455 @default.
• W2371440552 hasRelatedWork W1967031522 @default.
• W2371440552 hasRelatedWork W2188265758 @default.
• W2371440552 hasRelatedWork W2188867078 @default.
• W2371440552 isParatext "false" @default.
• W2371440552 isRetracted "false" @default.
• W2371440552 magId "2371440552" @default.
• W2371440552 workType "article" @default.