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- W2371442394 abstract "[Objective]To explore the preventive effect of low-dose Simvastain and captopril on rats with diabetic nephropathy.[Methods]Eighty S-D rats weighing 200 g were randomly divided into 5 groups,each of them consisted of 16 rats,normal control group(group E),diabetic mellitus control group(group D) and 3 drug intervention groups.Simvastain(group A),captopril(group B),both Simvastain and captopril(group C) were given to 3 intervention group separately after diabetes model developed.Clinical symptoms,biochemical,immunohistochemical and morphological value were observed 2 months later.[Results]The level of 24 hours urine albumin excretion of the rats in group A,B,C and D was high-er than that of the rats in group E in 1month,while it was lower in A,B and C group than that of in D group(P0.01).The level of 24 hours urinary albumin excretion of the rats in group A,B,C and D was higher than that of the rats in group E in 2 months,while it was lower in A,B and C group than that of in D group(P0.01 or P0.05).Blood glucose concentration was higher in group A,B,C and D than that in group E(P0.01),concentration of triglyceride was higher in group A,B,C and D than that in group E(P0.01 or P0.05),there was no difference of total cholesterin in the 5 groups(P0.05),the concentration of blood urine nitrogen was higher in group A,B,C and D than that in group E(P0.01),while the concentration of creatinine was lower in group A,B and C than that in group D(P0.01).There was no difference in group D and E(P0.05).[Conclusion]Low-dose Simvastain,captopril alone and in combination had preventive effect on rats with diabetic nephropathy,but the effect of Simvastain with the combination of captopril was not better than the effect of the drugs used alone." @default.
- W2371442394 created "2016-06-24" @default.
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- W2371442394 date "2010-01-01" @default.
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- W2371442394 title "Research on the Effect of Primary Prevention with Low-Dose Simvastain and Captopril to Rats with Diabetic Nephropathy" @default.
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