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- W2371448156 abstract "Objective To investigate the protective effect of hydrogen sulfide on LPS- induced acute lung injury in rats and its mechanism. Methods A total of 30 clean healthy male SD rats were selected and randomly divided into groups A,B,C,each of 10 rats. Rats of A group were given sublingual venous injection of 0. 9% sodium chloride injection( 0. 5 ml / kg),rats of B group were given sublingual venous injection of LPS( 5 mg / kg),rats of C group were given intraperitoneal injection of Na HS 28 μmol / kg before 15 minutes of sublingual venous injection of LPS( 5 mg / kg). Protein level and IL- 10 level of BALF,ICAM- 1 level of lung tissue were detected. Results Protein level and IL- 10 level of BALF,ICAM- 1 level of lung tissue of groups B and C were statistically significantly higher than those of A group, and above index of C group were statistically significantly lower than those of B group( P 0. 05). Conclusion Hydrogen sulfide has certain protective effect on LPS-induced acute lung injury,its mechanism is possibly related with decreasing of IL- 10 level and ICAM- 1 expression." @default.
- W2371448156 created "2016-06-24" @default.
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- W2371448156 date "2015-01-01" @default.
- W2371448156 modified "2023-09-28" @default.
- W2371448156 title "Protective Effect of Hydrogen Sulfide on LPS- induced Acute Lung Injury in Rats and Its Mechanism" @default.
- W2371448156 hasPublicationYear "2015" @default.
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