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- W2371469909 abstract "AIM To study if there were any changes of Bcl 2 expression and caspase 3 activity in vinorelbine(VRB) induced apoptosis of human lung cancer cell line Calu 3. METHODS Cells were incubated with VRB(20, 40 and 60 μmol·L -1 ) for 24 h. Morphological changes in apopto tic cells were studied by TUNEL FITC staining and acridine orange(AO) staining. Flow cytometer was used to detect apoptotic rates and Bcl 2 expression. Caspase 3 activity was detected by spectrofluorometer. RESULTS After treatment with VRB (20, 40 and 60 μmol·L -1 ) for 24 h, typical morphological features of apoptotic cells were appeared. Apoptotic rates of different concentrations of VRB treated cells were (3.1± 0.6) %,(7.8±1.2)% and (19.6±4.3)%, respectively, significantly higher than that of control cells(0%, P0.01). Bcl 2 expression rates of VRB treated cells were (37.6±6.9)%, (25.4±6.2)% and (8.4±2.5)%, respectively, much lower than that of control ones(48.3±7.1)% (P0.05, P0.01). Caspase 3 activity of VRB treated cells were (332±16), (416±11) and (631±27)μmol·L -1 ·h -1 , respectively, significantly higher than that of control ones (195±12) μmol·L -1 ·h -1 (P0.01). All changes were in a concentration dependent manner. CONCLUSION VRB can induce apoptosis of human lung cancer cells Calu 3 effectively through inhibiting Bcl 2 protein and activation of caspase 3 activity." @default.
- W2371469909 created "2016-06-24" @default.
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- W2371469909 date "2003-01-01" @default.
- W2371469909 modified "2023-09-23" @default.
- W2371469909 title "Vinorelbine-induced apoptosis of cultured human lung cancer cells and mechanisms" @default.
- W2371469909 hasPublicationYear "2003" @default.
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