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- W2371473185 abstract "Objectives To explore the role of protein kinase C (PKC) in regulating the activation of nuclear factor-кB (NF- кB) in T lymphocyte from idiopathic thrombocytopenic purpura (ITP) children. Methods Peripheral blood from ITP children (n = 35) and healthy children (n = 30) were collected. T lymphocytes were purified and divided into three groups separately: control group,phorbol 12- myristate 13- acetate (PMA) treated group,and PMA + H-7 treated group. The expression of NF- кB and inhibitor protein- кB (I- кB) was detected by immunohistochemical staining and Western blot,respectively. Results The percentage of cells with active NF- кB was significantly higher and the expression level of I- кB was significantly lower in ITP-PMA group than that in ITP- control group and healthy- PMA group respectively (all P 0.05). The percentage of cells with active NF- кB was significantly lower and the expression level of I- кB was significantly higher in ITP -PMA + H-7 group than that in ITP-PMA group(both P 0.05). Conclusions It revealed that the activation of NF- кB in ITP T lymphocyte may be regulated by PKC, and the activation of PKC- NF- кB signal pathway of T Lymphocyte may play an important role in the pathogenesis of ITP." @default.
- W2371473185 created "2016-06-24" @default.
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- W2371473185 date "2006-01-01" @default.
- W2371473185 modified "2023-09-25" @default.
- W2371473185 title "Signal transduction of protein kinase C regulating the activation of nuclear factor-кB in T lymphocytes from children with idiopathic thrombocytopenic purpura" @default.
- W2371473185 hasPublicationYear "2006" @default.
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