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- W2371488891 abstract "Objective To examine the dynamic variation of plasma nitric oxide(NO)level in newborn rats with hypoxic ischemic brain damage(HIBD)and their relation with hyperbaric oxygen(HBO)treatment.Methods To produce HIBD animal model by ligating the uterine arteries of pregnant rats.We detected the plasma NO level and nitric oxide synthetase(NOS)expression by radioimmunoassay and immunohistochemistry before operation and 6h,24h,72h,7d after HIBD and treatment with HBO.The pattern of neuronal cell death after HIBD was examined using TUNEL staining.Results Plasma NO level markedly elevated at 24h after HIBD,and NOS expression reached peak at 72h.The two parameters were significantly fell in the same groups treated with HBO.HBO also minimized eminently apoptosis of cerebral cells.Conclusions HIBD may be associated with the abnormal excretion of NO,and the mechanism of HBO treatment of newborn rats with HIBD may be associated with the reduction of plasma NO." @default.
- W2371488891 created "2016-06-24" @default.
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- W2371488891 date "2009-01-01" @default.
- W2371488891 modified "2023-09-26" @default.
- W2371488891 title "Dynamic variation of plasma nitric oxide levels in newborn rats with hypoxic ischemic brain damage and their relation with hyperbaric oxygen treatment" @default.
- W2371488891 hasPublicationYear "2009" @default.
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