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- W2371496893 abstract "Objective: To evaluate the effect ofBushen Formuladrug-containing serum on proliferation and apoptosis of SK-HEP-1 and to explore its mechanism. Methods: Drug-containing serums of SD rats were prepared and divided into blank group,Bushen Formulagroup and sorafenib group. SK-HEP-1 cells were cultured and VEGF-induced cell models were established. Each group was intervened by corresponding drug-containing serum. The proliferation of SK-HEP-1 cells was detected by MTT assay. Cell cycle and apoptosis were detected by flow cytometry. The expressions of bax mRNA and bcl-2 mRNA were detected by Real-time PCR. Results: Compared with blank serum group and VEGF group,the drug-containing serum ofBushen Formulagroup could significantly inhibit SK-HEP-1 cell proliferation( P 0. 01). Bushen Formula group could improve the ratio of G1phase( P 0. 05),improve apoptosis rate at early phase( P 0. 05) and total apoptosis rate( P 0. 05). Bushen Formulagroup could up-regulate the expression of bax mRNA( P 0. 05) and down-regulate the expression of bcl-2 mRNA( P 0. 01). There was no significant difference betweenBushen Formulagroup and sorafenib group( P 0. 05). Conclusion: Bushen Formulacan inhibit the proliferation and induce the apoptosis of human hepatoma cell line SK-HEP-1. Its mechanism may be related to arrest cells in S and G2phase from G1phase and up-regulate the bax expression and down-regulate the bcl-2 expression,which promotes the apoptosis of SK-Hep-1 cells." @default.
- W2371496893 created "2016-06-24" @default.
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- W2371496893 date "2014-01-01" @default.
- W2371496893 modified "2023-09-23" @default.
- W2371496893 title "Effect of “Bushen Formula”Drug-containing Serum on Proliferation and Apoptosis of Human Hepatoma Cells SK-HEP-1" @default.
- W2371496893 hasPublicationYear "2014" @default.
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