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- W2371521305 abstract "Objective:To study the effect of cardiotrophin-1(CT-1) on hypertrophy of cardiocytes induced by angiotensin Ⅱ(AngⅡ).Methods: The cultured cardiocytes were treated with AngII to induce hypertrophy and given with CT-1 antisense oligodeoxyribonucleotide(ASODN).The cell size and 3H-leucine incorporation were examined.The mRNA levels of CT-1 and β-myosin heavy chain(β-MHC)were examined by real-time PCR method.The protein expressions of CT-1 were examined by immunohistochemistry method.Results: Stimulated by AngⅡ,the cardiocytes were enlarged under the contrast phase microscope.After stimulated by AngⅡ,3H-leucine incorporation and the protein expression of CT-1 increased in the hypertrophic cardiocytes.The mRNA levels of CT-1 andβ-MHC increased also.Compared with hypertrophy group,the area of cardiocytes [(127.214±5.693) mm2 vs.(81.257±3.995) mm2],3H-leucine incorporation[(1971.50±42.16) cpm vs.(1653.33±17.91)cpm],protein expression of CT-1[(3.51±0.29)% vs.(3.16±0.17) %],CT-1 mRNA [(0.4023±0.0160) vs.(0.2137±0.0227)]and β-MHC mRNA[(0.773 4±0.0486)vs.(0.5032±0.0261)] significantly decreased in CT-1 ASODN group(given by CT-1 ASODN),P0.05~0.01.These indexes were no significantly difference among CT-1 MSODN(missence oligodeoxyribonucleotide)group,hypertrophy group and Fugene 6 group.Conclusion: Ang Ⅱ may induced the cardiocytes hypertrophy.The expression of CT-1 increased in hypertrophic cardiocytes stimulated by AngⅡ.The CT-1 ASODN inhibited the increased expression of CT-1 in hypertrophic cardiocytes stimulated by AngⅡ." @default.
- W2371521305 created "2016-06-24" @default.
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- W2371521305 date "2010-01-01" @default.
- W2371521305 modified "2023-09-23" @default.
- W2371521305 title "Effect of cardiotrophin-1 on hypertrophy of cardiocytes induced by angiotensin II" @default.
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