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- W2371528730 abstract "Objective To observe the therapeutic effect of Kuijieling Decoction on experimental ulcerative colitis rats.Methods Ulcerative colitis rat model was induced by enteroclysis with trinitro-benzene-sulfonic acid(TNBS).Three dosages(18.3 g/kg,9.2 g/kg,4.6 g/kg)of Kuijieling Decoction were used to treat the model rats.After treatment,the serum of rats were obtained to detect the level of IL-1β by enzyme-linked immunosorbent assay.Then the rats were killed for the observation of the colonic pathologic changes by naked eye and for the estimation of the damage scores of colon mucosa.Finally,the colon tissue was fixed to make pathological section and the damage index of colon mucosa was observed under microscope.Results The tissue damage scores of high-and moderate-dosage groups of Kuijieling Decoction were(2.41± 0.79)and(2.83± 0.71)respectively,and were significantly lower than that of model control group(3.75± 0.75;P 0.01).Observed under microscope,the pathological damage was significantly relieved in high-and moderate-dosage Kuijieling Decoction groups as compared with that in the model control group(P 0.05 or P 0.01).The serum level of IL-1β in high-and moderate-dosage Kuijieling Decoction groups was significantly lower than that in the model control group(P 0.01).Conclusion Kuijieling Decoction has protective effect against rat ulcerative colitis,and its mechanism may be related with the reduction of IL-1β ." @default.
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- W2371528730 date "2007-01-01" @default.
- W2371528730 modified "2023-09-26" @default.
- W2371528730 title "Pathological Observation of Therapeutic Action of Kuijieling Decoction on Ulcerative Colitis Rats" @default.
- W2371528730 hasPublicationYear "2007" @default.
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