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- W2371547575 abstract "[Objective]To observe the effects of Dachengqi Decoction(DD) on expression of toll-like receptor 4(TLR-4) in cell model of lung damage and explore the mechanisms involved. [Methods]Dachenqi Decoction and Medicated serum were prepared.Then human bronchial epithelial cells(HBEs) were divided into the following 7 groups :normal serum group,LPS group,low-dose medicated serum group,middle-dose medicated serum group,high-dose medicated serum group,Positive control group,and Negative control group).Expression of TLR-4 mRNA was assayed by immunocytochemistry Real-time PCR and Western blot. [Results]The inhibitory action of the high-dose medicated serum group was more obviously than the low-dose medicated serum group(P0.01).Compared to LPS group,the level of TLR-4 protein in the normal serum group was decreased(P0.01). [Conclusion]Dachenqi Decoction inhibits the expression of TLR-4 in human bronchial epithelial cells stimulated by LPS,which may indicate that DD has protective effect on damaged lung caused by LPS." @default.
- W2371547575 created "2016-06-24" @default.
- W2371547575 creator A5061668793 @default.
- W2371547575 date "2011-01-01" @default.
- W2371547575 modified "2023-09-23" @default.
- W2371547575 title "Effeet of Dachengqi Decoction on expression of TLR-4 in human bronchial epithelial cells stimulated by LPS" @default.
- W2371547575 hasPublicationYear "2011" @default.
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