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- W2371553202 abstract "Objective:To investigate the effect of 9 cis RA on the differentiation and apoptosis of human lung squamous carcinoma cell lines(L78 and A2).Methods:Cell number and morphology were observed at 0,12,24,36,48,72h respectively after the treatment to the two study groups,the effect of 9 cis RA on the cell cycle and expression of Bcl 2 in L78 and A2 was also examined.Results:9 cis RA significantly decreased the number of L78 and A2 ( P0.05 ,24h; P 0.01,36h).Studies implicated G1 phage of the cell cycle was arrested,the percentage of G0/G1 phage increased( P 0.01,22h),and the percentage of S phage cells decreased( P 0.01,24h).Cell cycle arrest was associated with increased apoptosis and decreased expression of Bcl 2 protein.Conclusion:9 cis RA potently inhibited the growth of human squamous cancer cells in vitro,induced the differentiation and apoptosis of the cells." @default.
- W2371553202 created "2016-06-24" @default.
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- W2371553202 date "2001-01-01" @default.
- W2371553202 modified "2023-09-25" @default.
- W2371553202 title "EFFECT OF 9-CIS-RETINOIC ACID ON DIFFERENTIATION AND APOPTOSIS OF HUMAN LUNG CARCINOMA CELL LINES" @default.
- W2371553202 hasPublicationYear "2001" @default.
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