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- W2371559781 abstract "Aim:Oxidative stress is believed to play an important role in the development of hypertension associates with diabetes mellitus in animal models.To test this hypothesis in humans,we determined to evaluate the markers of polymorphonuclear leukocyte oxygen free radical( OFR)production,lipid peroxidation and defenses against oxidative stress in NIDDM patients with and without Methods and Results:A convenient and senstive method for estimation of neutrophil OFR production was assayed by polymorphonuclear leukocyte chemiluminescence(PMN CL).We have measured the parameters of PMN CL, the plasma malondialdehyde(MDA) concentration, the plasma activities of superoxide dismutase(SOD) and glulathione peroxidase(GSHPx) in 136 NIDDM patients( 70 without hypertension and 66 with hypertension) and 30 age matched healthy subjects. Patients with hypertension showed significantly increased PMN CL parameters as peak value(974.8±357.7 mV),integration(149368±74761 mV·s) , and phagocytic index(0.298±0.131 mV·mm -3 ) compared to diabetics without hypertension(572.3±106.8 mV,79038±24137 mV and 0.213±0.079 mV·mm -3 ) and healthy controls(275.9±65.2 mV,36631±9442 mV·s,and 0.078±0.045 mV·mm -3 ).( P 0. 01,respectively). The plasma MDA concentration(4.87±0.13 nmol·ml -1 ) increased in patients with hypertension compared with that in diabetics without hypertension(4.18±0.21 nmol·ml -1 ) and healthy controls(3.42±0.29 nmol·ml -1 ),( P 0.01,respectively).The PMN CL peak value correlated best with plasma MDA concentration ( r =0.7486, P 0.01, n =66) and negatively correlated with the plasma activity of SOD ( r =-0.6471, P 0.05, n =66). Conclusion:These data confirm that the oxidative stress was significant in NIDDM patients and was enchaned in diabetic patients with hypertension." @default.
- W2371559781 created "2016-06-24" @default.
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- W2371559781 date "1999-01-01" @default.
- W2371559781 modified "2023-09-26" @default.
- W2371559781 title "Oxidative Stress Is Present in NIDDM and Further Enchaned by ;Hypertension" @default.
- W2371559781 hasPublicationYear "1999" @default.
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