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- W2371560246 abstract "Objectives To identify the sentinel lymph nodes (SLN) in patients with breast cancer,study a sensitive method for the detection of breast cancer micro-metastases in lymph nodes,and evaluate their clinical significance.Methods 48 patients with breast cancer underwent lymphatic mapping using a patent blue dye alone (28 cases)and a combination of a patent blue dye and 99mTc-DX(20 cases).The SLN was identified and removed,followed by a definitive cancer operation,including a complete axillary node dissection.20 patients' micro-metastases in axillary lymph nodes(including 48 SLNs and 191 NSLNs) were detected by immunohistochemical and reverse transcriptase-polymerase chain reaction(RT-PCR).Results The SLN was successfully identified in 44 patients (91.7%).Of 48 patients,20 patients using a combination of apatent blue dye and 99mTc-DX were all successfully identified.95 SLNs and 457 NSLNs were found in 44 patients with successful lymphatic mapping.36 nodes were found to have metastases in 95 SLNs(37.9%),and 73 nodes were found to have metastases in 457 NSLNs(19.7%),P= 0.000 2 .Of 48 SLNs,Micro-metastases positive rate was14.6%(7/48) by histological examination,29.2%(14/48) by EMA immunohistochemical assay,22.9%(11/48) by CK-19 immunohistochemical assay,62.5%(30/48)by RT-PCR assay.Of 191 NSLNs,Micro-metastases positive rates were 0,1.6%(3/191),1.1%(2/191),11.5%(22/191) by histological examination,EMA immunohistochemical assay,CK-19 immunohistochemica assay,and RT-PCR assay,respectively(P0.01).Conclusion The success rate achieved by combining the two mapping techniques is higher than the rate by using either technique alone;immunohistochemical assay,and CK-19 mRNA RT-PCR are more sensitive than histology for the detection of micrometastases in lymph nodes,and the RT-PCR is better than immunohistochemical assay.The techniques are significant for the treatment of breast cancer." @default.
- W2371560246 created "2016-06-24" @default.
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- W2371560246 date "2006-01-01" @default.
- W2371560246 modified "2023-09-25" @default.
- W2371560246 title "Lymphatic mapping,sentinel node biopsy and micro-metastasis detecting in the patient with breast cancer and their clinical significance" @default.
- W2371560246 hasPublicationYear "2006" @default.
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