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- W2371566771 abstract "Objective: To investigate the effects of nitric oxide(NO)precursor L-Arg and NOS inhibitor L-NAME on collagen synthesis induced by angiotensin Ⅱ(Ang II) in cardiac fibroblast(CFs).Methods: The CFs of neonatal SD rat were separated,purified and cultured using trypsin digestion method.Hydroxyproline concentration of CFs was determined and calculated by hydroxyproline standard curve,and the collagen concentration was equal to 7.4 times of hydroxyproline concentration.Results:(1) When adding Ang Ⅱ to the culture solution at the dosage of 10-9 ~ 10-5 mol / L,collagen concentration increased in a dose-dependent manner.(2) Saralasin and PTX had no significant effects on collagen concentration of CFs;however,they can inhibit AngⅡ from inducing collagen sythesis in CFs.(3) Adding NO precursor L-Arg before Ang Ⅱ can significantly weaken the inducing effects of AngⅡ in CFs collagen sythesis.(4)The effects of L-Arg may be inhibited by pretreatment of L-NAME,a NOS blocker.(5) The inducing effect of Ang Ⅱin CFs collagen sythesis was strengthened by NOS blocker L-NAME.Conclusions: These results indicate that collagen concentration of CFs can be significantly increased by Ang Ⅱin a dose-dependent manner,which was mediated by Ang Ⅱreceptor and probably may be partially dependent on PTx-sensitive G protein.NO can significantly inhibited Ang Ⅱform the inducing collagen sythesis.The L-Arg-NO pathway may exist in CFs and probably play an important role in the process of the collagen sythesis induced by Ang Ⅱ." @default.
- W2371566771 created "2016-06-24" @default.
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- W2371566771 date "2009-01-01" @default.
- W2371566771 modified "2023-09-23" @default.
- W2371566771 title "Role of NO on collagen synthesis induced by Ang IIand its mechanism in the cardiac fibroblast" @default.
- W2371566771 hasPublicationYear "2009" @default.
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