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- W2371567472 abstract "Purpose:To study the expression of MT1-MMP ,EMMPRIN and P-gp in gastric carcinoma and the relation of invasion, metastasis with drug resistance in gastric carcinoma. Methods:Detected membrane-type-1 matrix metalloproteinase (MT1-MMP), extra-cellular matrix metalloproteinase inducer (EMMPRIN), P-glycoprotein (P-gp) in gastric carcinoma by immunohistochemical method. Results:Among 40 cases of gastric carcinoma, there were 15 cases (37.5%) MT1-MMP-positive, 26 cases (65%) EMMPRIN-positive, 23 cases (57.5%) P-gp-positive respectively. The over-expression of MT1-MMP, EMMPRIN, P-gp was associated with invasive depth and lymph node matasteses of tumor cells(P(0.05)). Immunohistiochemically, they were divided into two groups: P-gp-positive and P-gp-negative . The following item were significantly more frequent in the P-gp-positive group: EMMPRIN-positive (P0.01), MT1-MMP-positive (P(0.05)).The expression of MT1-MMP in the EMMPRIN-positive group was more frequent than that in the EMMPRIN-negative group (P0.05). However, among 20 non-cancerous cases there was only one case positive for EMMPRIN and another case positive for P-gp. Conclusions:There was an close relationship between MT1-MMP, EMMPRIN and P-gp in gastric carcinoma, it indicated that during the progression of gastric carcinoma there was a close relationship between invasion, metastasis and drug resistance." @default.
- W2371567472 created "2016-06-24" @default.
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- W2371567472 date "2005-01-01" @default.
- W2371567472 modified "2023-09-23" @default.
- W2371567472 title "Expression of MT1-MMP, EMMPRIN, P-gp in gastric carcinoma and their correlation" @default.
- W2371567472 hasPublicationYear "2005" @default.
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