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- W2371569175 abstract "Objective To investigate the capability of dendritic cells(DCs) from peripheral blood of the patients with psoriasis vulgaris for stimulating T lymphocytes to proliferate and differentiate in vitro.Methods DCs of peripheral blood in patients with psoriasis vulgaris were cultured for five days with medium containing GM-CSF and IL-4.CD83 and CD86,the surface markers of DCs,were detected by flow cytometry.The levels of IL-12,IL-4,IL-1β and IFN-γ in the cell culture supernatant were detected by ELISA.Results Compared with health group,the expression of CD83 and CD86 on DCs in the patient group were all increased evidently(P0.01).The level of IL-12 was increased markedly(P0.05),but the productions of IL-4 and IL-1β were decreased obviously(P0.001).No difference was found for the production of IFN-γ.Conclusion The capability of antigen presentation and of DCs in the patients with psoriasis vulgaris was increased evidently,which promoted the activation and differentiation of T lymphocytes from Th0 to Th1." @default.
- W2371569175 created "2016-06-24" @default.
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- W2371569175 date "2008-01-01" @default.
- W2371569175 modified "2023-09-22" @default.
- W2371569175 title "Study in vitro on specific immune function of dendritic cells in peripheral blood of patients with psoriasis vulgaris" @default.
- W2371569175 hasPublicationYear "2008" @default.
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