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• W2371591243 abstract "Objective To observe the precautionary and therapeutic effects of Xiaowei Fangshi Decoction on the micro calcium oxalate kidney stones of rats and to explore its mechanisms preliminarily. Methods 72 Wistar rats were divided randomly by random digits table into the normal group,the saline negative control group,the Compound Loosestrife Particles positive control group,the low dose Xiaowei Fangshi Decoction experimental group,the medium dose Xiaowei Fangshi Decoction experimental group, the high dose Xiaowei Fangshi Decoction experimental group. Except those in the normal group,rats in the rest groups received Glycol every morning for 5 consecutive days. In addition,the saline negative control group,the Compound Loosestrife Particles positive control group,the low dose Xiaowei Fangshi Decoction experimental group,the medium dose Xiaowei Fangshi Decoction experimental group,the high dose Xiaowei Fangshi Decoction experimental group received normal saline,Compound Loosestrife Particles Solution, the low dose Xiaowei Fangshi Decoction,the medium dose Xiaowei Fangshi Decoction,the high dose Xiaowei Fangshi Decoction respectively every afternoon for 5 consecutive days. After the last drench on the fifthday,the rats in all groups were collected 12h urine,weighed,drawed abdominal aortic blood and taken kidneys. Each group of urine was taken the supernatant after centrifugation,and then measured pH,oxalic acid,calcium,creatinine. Each group of abdominal aortic blood was taken the serum after centrifugation, and then measured oxalic acid,calcium,creatinine. Each group of kidneys was weighted,and then made into tissue slices. Results The extent of stone in the six groups was statistically significant( P 0. 01); Compared with the saline negative control group,the differences in the Compound Loosestrife Particles positive control group and the low dose Xiaowei Fangshi Decoction experimental group were not statistically significant( all P 0. 05),but the medium dose Xiaowei Fangshi Decoction experimental group and the high dose Xiaowei Fangshi Decoction experimental group were statistically significant respectively( P 0. 05,P 0. 01); Compared with the Compound Loosestrife Particles positive control group,the differences in the low dose Xiaowei Fangshi Decoction experimental group,the medium dose Xiaowei Fangshi Decoction experimental group and the high dose Xiaowei Fangshi Decoction experimental group were not statistically significant( all P 0. 05). The overall differences of the pH in the urine,the oxalic acid,calcium,creatinine in the urine and the serum in the six groups were not statistically significant respectively( all P 0. 05); Compared with the normal group and the saline negative control group,the medium dose Xiaowei Fangshi Decoction experimental group and the high dose Xiaowei Fangshi Decoction experimental group were not statistically significant respectively( all P 0. 05). The differences of left kidney weight,right kidney weight and final rat weight were statistically significant respectively( P 0. 05,P 0. 01,P 0. 01). Conclusion Xiaowei Fangshi Decoction has precautionary and therapeutic effects on the micro calcium oxalate kidney stones of rats. It is maybe the mechanism that Xiaowei Fangshi Decoction makes the calcium oxalate crystals to reduce through the influence on the attachment and discharge of calcium oxalate crystals, rather than through the influence of the pH in the urine,the oxalic acid,calcium,creatinine in the urine and the serum on the formation of calcium oxalate crystals." @default.
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• W2371591243 date "2014-01-01" @default.
• W2371591243 modified "2023-09-23" @default.
• W2371591243 title "Precautionary and therapeutic effects of Xiaowei Fangshi Decoction on the micro calcium oxalate kidney stones of rats and its mechanisms: an experimental research" @default.
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