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- W2371592686 abstract "Objective: To establish an animal model of rickets for studying its clinical changes in bone mineral density to offer a guide in prevention and therapy of rickets in pediatric practice. Methods: 42 twenty-one day SD rats were randomly divided into rickets model (32 rats) and normal model (10 rats). The experimental group kept from sunlight and fed with Vitamin D deficient diet for six weeks. The weight, high, fur, appetite, X-ray and the bone mineral density of lumbar vertebrae were measured in both groups for comparison. Then the rickets rats were randomly divided 3 groups and treated with different therapies. Results: The rickets rats’ metaphases were splayed and there was an expanding of epiphysis line. The weight and high of the experimental group showed significant differences against normal group (P0.05). BMD of the lumbar vertebrate of the rickets rats was decreased against normal (P0.001). A single dose of Vitamin D 150000U injected intramuscularly was the best way of treatment of rickets. Conclusion: The rickets model was successfully established in young SD rats with Vitamin D deficiency and kept from sunlight over a period of six weeks. Bone mineral density was decreased much in rickets rats. Treatment of rickets mainly depends on Vitamin D." @default.
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- W2371592686 date "2004-01-01" @default.
- W2371592686 modified "2023-09-25" @default.
- W2371592686 title "Establishment of Rickets Rats Model and Study of Its Bone Mineral Density" @default.
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