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- W2371593760 abstract "AIM To investigate the effect of carvedilol on acute renal failure induced by cisplatin in rats and explore the possible mechanism.METHODS Male Wistar rats were given ig carvedilol 5,15 and 30 mg·kg-1,respectively,once daily for 6 d,and single dose of cisplatin 10 mg·kg-1 ip at d 3.Renal injury was assessed by measuring serum creatinine(SCr),blood urea nitrogen(BUN),N-acetyl-β-D-glucosaminidase(NAG)in urine and the renal morphology changes by hematoxylin-eosin(HE)staining,as well as the malondialdehyde(MDA)content,superoxide dismutase(SOD)activity and glutathione peroxidase(GSH-Px)activity of the kidney were measured.RESULTS Cisplatin induced a significant increment in SCr,BUN,NAG,and MDA content and severe morphology changes,at the same time,decreased the renal SOD and GSH-Px activities.Pre-treatment with carvedilol 5 and 15 mg·kg-1 reversed the changes mentioned above.CONCLUSIONIn some dosage range,carvedilol improves acute renal failure induced by cisplatin through reducing reactive oxidative species and increasing the activity of antioxidases." @default.
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- W2371593760 date "2007-01-01" @default.
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- W2371593760 title "Protective effect of carvedilol on acute renal failure induced by cisplatin in rats" @default.
- W2371593760 hasPublicationYear "2007" @default.
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