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- W2371595192 abstract "Objective To investigate the inhibitory effect of human hepatocyte growth factor(HGF) via a recombinant adenovirus mediated HGF gene(Ad-HGF) on apoptotic cells in the lung tissue of passive smoking rats.Methods Forty Wistar rats in good conditions were randomly divided into four groups:control group(group A),emphysema group(Group B), emphysema+Ad-HGF group(Group C) and emphysema+Ad-GFP group(Group D), 10 rats each group.Group B, C, D rats were treated with smoke for 12 weeks to induce emphysema modes.Group B, C and D were intratracheally instilled with 0.5 mL normal saline, 1×109pfu Ad-HGF and 1×109pfu Ad-GFP respectively and Group A rats were normally feeded.Fourteen days after treatment and then killed the rats.Frozen sections of lung tissues from Group D were prepared and observed under fluorescence microscopy and the pathological sections of lung tissues from Group A, B and C were prepared to calculate the Mean Alveoli Area(MAA), Mean Linear intercept(MLI) and Mean Alveoli Number(MAN).Terminal deoxynucleotidy transferase-mediated dUTP nick end labeling(TUNEL) methods were carried out to examine the percentage of positive cells and distribution of apoptotic cells in the lung tissue.Results Compared with Group A, the lung tissues of Group B, C and D all had pathological changes in different degrees.Compare with Group B, the MAA and MLI of Group C were much less(p0.05), but the MAN were more(p0.05).TUNEL staining showed that Group B and C both had more apoptotic cells than Group A(p0.05), but Group C had less apoptotic cells than Group B(p0.05).Conclusion Ad-HGF had some inhibitory effects on apoptotic cells in the lung tissue of smoke induced emphysema in rats." @default.
- W2371595192 created "2016-06-24" @default.
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- W2371595192 date "2009-01-01" @default.
- W2371595192 modified "2023-09-26" @default.
- W2371595192 title "Inhibit apoptosis effect of Ad-HGF on pulmonary emphysema induced by smoking in rats" @default.
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