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- W2371598868 abstract "OBJECTIVE To investigate the association between TNF-αrs1800629polymorphisms and the risk of endometrial cancer in Han women from Northeast China.METHODS Genotyping of rs1800629 in the TNF-αgene was performed by PCR-restriction fragment length polymorphism(PCR-RFLP)of peripheral blood samples in 263 endometrial cancer patients(case)and 315 healthy subjects(control).RESULTS In the analysis of the risks of endometrial cancer,BMI≥24,hypertension and diabetes was three high risk factors.In the case group the rates of the three factors were37.3%,39.5% and 14.4%,repectively.In the control group,the rates were 29.2%,11.7% and 5.1%,respectively(P=0.041,0.001and0.001).Allele frequency of rs1800629 in case group was 13.3%,which was significantly increased than 8.9%in control group(P=0.017).The AA genotype frequency of rs1800629 in case group was 7.2%,which was also significantly increased than 3.5%in control group(P=0.043).Simple factor analysis showed that AA genotype increased the risk of endometrial cancer(OR=2.200,95%CI:1.025-4.723).After multiple regression analysis corrected,it showed that the AA genotype did not increase the risk of endometrial cancer(OR=1.274,95%CI:0.322-5.039,P=0.730).The frequencies of AA genotype in well,mediate and poor differentiated group were 10.2%,4.4% and 6.7%,that were not correlated with differentiation(P=0.386).CONCLUSIONS We demonstrate that in Han women from Northeast China,rs1800629 polymorphism of TNF-αgene was not associated with the risk of endometrial cancer." @default.
- W2371598868 created "2016-06-24" @default.
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- W2371598868 date "2014-01-01" @default.
- W2371598868 modified "2023-09-27" @default.
- W2371598868 title "Relationship between TNF-α rs1800629 polymorphism and endometrial cancer" @default.
- W2371598868 hasPublicationYear "2014" @default.
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