FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2371607386> ?p ?o ?g. }

• W2371607386 endingPage "544" @default.
• W2371607386 startingPage "541" @default.
• W2371607386 abstract "Objective To investigate the role of coagulation activity of bronchoalveolar lavage fluid (BALF) in the pathogenesis of lung fibrosis. Methods Fourty-eight Sprague-Dawley rats were randomly divided into 2 groups, 24 rats in each group. In the bleomycin (BLM) group, the lung fibrosis model was made by tracheal instillation of bleomycin A(5) (BLMA(5), 5 mg/kg). At day 7, 14, 28 and 40, the recalcification time of normal pooled plasma, factor VII and X deficiency plasma were measured for procoagulation activity (PCA), and the thrombin activity and the protein level of transforming growth factor beta(1) (TGF-beta(1)) in BALF were also measured. In the control group, normal solution was instillated into the lungs. Results In the BLM group, the recalcification time of normal pooled plasma in BALF at the four time points were (56 +/- 10), (78 +/- 4), (172 +/- 11) and (180 +/- 6) s respectively, while in the control group, were (190 +/- 10), (186 +/- 8), (184 +/- 6) and (185 +/- 6) s respectively. The thrombin activity at the four time points were (1.26 +/- 0.03), (0.82 +/- 0.05), (0.28 +/- 0.03) and (0.28 +/- 0.02) microg/ml respectively in the BLM group, but were (0.31 +/- 0.02), (0.32 +/- 0.03), (0.31 +/- 0.04) and (0.29 +/- 0.05) microg/ml respectively in the control group. The level of TGF-beta(1) at the four time points were (310 +/- 36), (220 +/- 30), (109 +/- 12) and (96 +/- 11) ng/ml respectively in the BLM group, but were (92 +/- 20), (94 +/- 12), (92 +/- 10) and (90 +/- 9) ng/ml respectively in the control group. The above measurements were significantly different in day 7 and 14 between the BLM group and the control group (P 0.01). In the BLM group, at day 7 and 14, the recalcification time of factor VII deficiency plasma was (123 +/- 12) and (162 +/- 4) s respectively; the recalcification time of factor X deficiency plasma was (357 +/- 22) and (387 +/- 12) s respectively; the recalcification time of factor X deficiency plasma was longer than that of factor VII deficiency plasma and that of normal pooled plasma. Within 14 day, the level of TGF-beta(1) was positively correlated with PCA and thrombin activity. Conclusions During the period of alveolitis, the PCA and thrombin activity were upregulated in BALF, which was caused by activated factor VII activating factor X and the switching to the exogenous coagulation pathway. But during the period of lung fibrosis, their activities were not upregulated. These results suggest that the coagulation factor and thrombin might contribute to the development of pulmonary fibrosis by promoting production of TGF-beta(1)." @default.
• W2371607386 created "2016-06-24" @default.
• W2371607386 creator A5046796483 @default.
• W2371607386 creator A5049861137 @default.
• W2371607386 creator A5070373092 @default.
• W2371607386 creator A5089925306 @default.
• W2371607386 creator A5090076330 @default.
• W2371607386 date "2005-04-07" @default.
• W2371607386 modified "2023-09-23" @default.
• W2371607386 title "[The change and significance of coagulation activity in bleomycin-induced lung fibrosis in rats]." @default.
• W2371607386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16207402" @default.
• W2371607386 hasPublicationYear "2005" @default.
• W2371607386 type Work @default.
• W2371607386 sameAs 2371607386 @default.
• W2371607386 citedByCount "1" @default.
• W2371607386 countsByYear W23716073862020 @default.
• W2371607386 crossrefType "journal-article" @default.
• W2371607386 hasAuthorship W2371607386A5046796483 @default.
• W2371607386 hasAuthorship W2371607386A5049861137 @default.
• W2371607386 hasAuthorship W2371607386A5070373092 @default.
• W2371607386 hasAuthorship W2371607386A5089925306 @default.
• W2371607386 hasAuthorship W2371607386A5090076330 @default.
• W2371607386 hasConcept C126322002 @default.
• W2371607386 hasConcept C134018914 @default.
• W2371607386 hasConcept C142724271 @default.
• W2371607386 hasConcept C2776232574 @default.
• W2371607386 hasConcept C2776694085 @default.
• W2371607386 hasConcept C2777714996 @default.
• W2371607386 hasConcept C2777961210 @default.
• W2371607386 hasConcept C2778382381 @default.
• W2371607386 hasConcept C2780559512 @default.
• W2371607386 hasConcept C2780942790 @default.
• W2371607386 hasConcept C2781244666 @default.
• W2371607386 hasConcept C2908744134 @default.
• W2371607386 hasConcept C71924100 @default.
• W2371607386 hasConcept C90924648 @default.
• W2371607386 hasConceptScore W2371607386C126322002 @default.
• W2371607386 hasConceptScore W2371607386C134018914 @default.
• W2371607386 hasConceptScore W2371607386C142724271 @default.
• W2371607386 hasConceptScore W2371607386C2776232574 @default.
• W2371607386 hasConceptScore W2371607386C2776694085 @default.
• W2371607386 hasConceptScore W2371607386C2777714996 @default.
• W2371607386 hasConceptScore W2371607386C2777961210 @default.
• W2371607386 hasConceptScore W2371607386C2778382381 @default.
• W2371607386 hasConceptScore W2371607386C2780559512 @default.
• W2371607386 hasConceptScore W2371607386C2780942790 @default.
• W2371607386 hasConceptScore W2371607386C2781244666 @default.
• W2371607386 hasConceptScore W2371607386C2908744134 @default.
• W2371607386 hasConceptScore W2371607386C71924100 @default.
• W2371607386 hasConceptScore W2371607386C90924648 @default.
• W2371607386 hasIssue "8" @default.
• W2371607386 hasLocation W23716073861 @default.
• W2371607386 hasLocation W23716073862 @default.
• W2371607386 hasOpenAccess W2371607386 @default.
• W2371607386 hasPrimaryLocation W23716073861 @default.
• W2371607386 hasRelatedWork W2236706150 @default.
• W2371607386 hasRelatedWork W2345671491 @default.
• W2371607386 hasRelatedWork W2354325741 @default.
• W2371607386 hasRelatedWork W2359307160 @default.
• W2371607386 hasRelatedWork W2359640985 @default.
• W2371607386 hasRelatedWork W2359867284 @default.
• W2371607386 hasRelatedWork W2361164883 @default.
• W2371607386 hasRelatedWork W2368676528 @default.
• W2371607386 hasRelatedWork W2368801302 @default.
• W2371607386 hasRelatedWork W2378011965 @default.
• W2371607386 hasRelatedWork W2378123706 @default.
• W2371607386 hasRelatedWork W2378137278 @default.
• W2371607386 hasRelatedWork W2379383935 @default.
• W2371607386 hasRelatedWork W2380320421 @default.
• W2371607386 hasRelatedWork W2384226303 @default.
• W2371607386 hasRelatedWork W2386132686 @default.
• W2371607386 hasRelatedWork W2386524520 @default.
• W2371607386 hasRelatedWork W2391862952 @default.
• W2371607386 hasRelatedWork W3030009941 @default.
• W2371607386 hasRelatedWork W96804527 @default.
• W2371607386 hasVolume "28" @default.
• W2371607386 isParatext "false" @default.
• W2371607386 isRetracted "false" @default.
• W2371607386 magId "2371607386" @default.
• W2371607386 workType "article" @default.