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- W2371609172 abstract "Objective To investigate the effect of Simvastatin on hypercholesterolemia in a Mongolian gerbil medel.Methods The Mongolian gerbils were fed with high-fat diet and treated by simvastatin at different concentrations to inhibit endogenic cholesterol biosynthesis.The color of liver,body weight,liver weight,TC,LDL-C,HDL-C,AST and ALT were observed or measured to assess the surum lipid and liver function.Results The body weight,liver weight and liver coefficient were not significantly different in different groups.The high-fat diet enhanced lipid deposition in the liver,but not significant affect the liver function,including AST and AST.Simvastatin significantly decreased the surum TC,LDL-C.HDL-C,TBA and GLU,but did not significantly changed other indexes.Conclusion A Mongolian gerbil model of hypercholesteremia can be established within a short period by high-fat diet feeding.Simvastatin can significantly inhibit endogeneous cholesterol biosythesis,therefore,delay the development of hypercholesteremia model.The results indicate that endogenic cholesterol synthesis plays an important role in hypercholesterolemia in the Mongolian gerbils.The special feedback regulation in cholesterol biosynthesis may be a major reason of hypercholesterolemia in Mongolian gerbils." @default.
- W2371609172 created "2016-06-24" @default.
- W2371609172 creator A5023731759 @default.
- W2371609172 date "2010-01-01" @default.
- W2371609172 modified "2023-09-23" @default.
- W2371609172 title "Establishment of a Mongolian Gerbil Model of Hypercholesterolemia and the Effect of Simvastatin" @default.
- W2371609172 hasPublicationYear "2010" @default.
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