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- W2371617163 abstract "Objective:To study the clinical implication of C-reaction Protein(CRP)in patients with HBV infection,and explore the effect of hepatitis B virus(HBV) on the expression of CRP at the cellular level.Methods:Serum CRP levels in patients with HBV infection and healthy individuals were measured by Behring nephelometer systems(BNⅡ),the expression of CRP difference among patients with chronic hepatitis B,liver cirrhosis and hepatocellular carcinoma were analyzed.Then mRNA expression of CRP in HepG2 and HepG2.2.15 cells was measured by RT-PCR.Results:The serum CRP level was higher in HBV patients as compared to healthy individuals,and the total differences were of statistical significance(F=21.38,P0.01).Especially the average serum levels of CRP was much higher in patients with hepatocellular carcinoma than other patients(P0.01).Expression of CRP mRNA was higher in HepG2.2.15 cells than in HepG2 cells.Conclusion:The serum CRP level is associated with the disease progression,and HBV can increase the expression of CRP." @default.
- W2371617163 created "2016-06-24" @default.
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- W2371617163 date "2011-01-01" @default.
- W2371617163 modified "2023-09-25" @default.
- W2371617163 title "The clinical implication of C-reaction protein in patients with HBV infection and related research at the cellular level" @default.
- W2371617163 hasPublicationYear "2011" @default.
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