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- W2371628305 abstract "Objective:To compare the acute toxicities of aqueous and ethanol extracts obtained from different processed products of Aconiti Lateralis Radix Praeparata(Fuzi).Method:Acute toxical tests were carried out on SPF-level mice by gavage to get the median lethal dose(LD50) for ethanol extracts of Black slice(Heishunpian,H),White slice(Baishunpian,B) and the raw daughter root(Nifuzi,N) or carried out on SPF-level mice and rats to get the maximum tolerated dose(MTD) for aqueous extracts from these three processed products.Acute toxical reactions were observed and compared.Result:Expressed in raw drugs,the LD50 of ethanol extracts from H,W,N was 49.853,42.550,22.169 g﹒kg-1 respectively for mice by oral administration.Given orally,the MTD for aqueous extracts from H,W,N was 48.80,59.00,92.80 g﹒kg-1 for mice and 48.80,59.00,46.40 g﹒kg-1 on rats respectively.The toxical reactions were not all the same among these six extracts.Conclusion:The ethanol extracts of Fuzi are more toxic than the aqeuous extracts and among the six extracts the ethanol extract of N is the most toxic." @default.
- W2371628305 created "2016-06-24" @default.
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- W2371628305 date "2012-01-01" @default.
- W2371628305 modified "2023-09-23" @default.
- W2371628305 title "Comparative study on acute toxicity of extracts from different processed products of Aconiti Lateralis Radix Praeparata" @default.
- W2371628305 hasPublicationYear "2012" @default.
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