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- W2371633398 abstract "Objective: To investigate a new method to cure acute myocardial ischemia with human umbilical cord blood stem cells (HUCBSC) transplantation. Methods: 40 New Zealand rabbits were randomly divided into two groups-intervention group and control group. The left anterior descending branch of coronary artery was ligated to construct acute myocardial ischemia model. After 60-minute ischemia of the myocardium, 0.3ml of HUCBSC (the concentration was 10~(8) cells per milliliter) was transplanted into the ischemic myocardium of rabbits in intervention group, while the same volume of human vein blood was transplanted into the ischemic myocardium of rabbits in control group as well. 3 weeks later, the myocardial function, the myocardial infarct size, creatine kinase(CK), malondialehyde(MDA)and superoxide dismutase(SOD)concentration in serum of both group were investigated. Results: Left ventricular systolic pressure (LVSP) and ±dp/dtmax of left ventricle of rabbits in intervention group were much higher than those in control group (P0.01),however, left ventricular end diastolic pressure (LVEDP) of rabbits in intervention group was lower obviously than that of control group (P0.01). The myocardial infarct sizes of rabbits in intervention group were smaller than those in control group (P0.01), the serum concentration of CK and MDA of rabbits in intervention group were lower in evidence than those in control group (P0.01), while the concentration of serum SOD in rabbits of intervention group was higher than that of control group (P0.05). Conclusion: Transplantation of HUCBSC can improve myocardial function, abate myocardial injury due to oxygen free radicals and reduce myocardial infarct size of ischemic myocardium in rabbit." @default.
- W2371633398 created "2016-06-24" @default.
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- W2371633398 date "2005-01-01" @default.
- W2371633398 modified "2023-09-27" @default.
- W2371633398 title "Laboratory Study on Acute Myocardial Ischemia Treated by Transplantation with Human Umbilical Cord Blood Stem Cells" @default.
- W2371633398 hasPublicationYear "2005" @default.
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